Category Archives: Health

What are the CYP2CP substrates that piperine might interfere with?

CYP2C9 Substrates

  • Alosetron (Lotronex)
  • Bosentan (Tracleer)
  • Candesartan (Atacand)
  • Celecoxib (Celebrex)
  • Chlorpropamide (eg, Diabinese)
  • Diclofenac (Voltaren)
  • Dronabinol (Marinol)
  • Flurbiprofen (Ansaid)
  • Fluvastatin (Lescol)
  • Glimepiride (Amaryl)
  • Glipizide (Glucotrol)
  • Glyuride (DiaBeta)
  • Ibuprofen (eg, Motrin, Advil)
  • Indomethacin (Indocin)
  • Irbesartan (Avapro)
  • Losartan (Cozaar)
  • Meloxicam (Mobic)
  • Montulukast (Singulair)
  • Naproxen (eg, Aleve)
  • Nateglinide (Starlix)
  • Phenobarbital
  • Phenytoin (eg, Dilantin)
  • Piroxicam (Feldene)
  • Rosiglitazone (Avandia)
  • Rosuvastatin (Crestor)
  • Sulfamethoxazole
  • Tolbutamide
  • Torsemide (Demadex)
  • Valsartan (Diovan)
  • Warfarin (Coumadin)

CYP2C9 Inducers

  • Aminoglutethimide
  • Barbiturates
  • Bosentan (Tracleer)
  • Carbamazepine (eg. Tegretol)
  • Griseofulvin
  • Phenytoin (eg. Dilantin)
  • Primidone
  • Rifabutin
  • Rifampin (eg, Rifadin)
  • Rifapentine
  • St. John’s Wort

    I have TMJ from chewing too much gum, how do I fix this?

    Chewing gum too often or for too long can sometimes cause TMJ in people.  You may notice any of the following symptoms:

    1. Jaw is tight on the side you chew gum on.
    2. It’s hard to fully bite down.
    3. There is pain in the jaw at the joint.
    4. You might have ringing in the ear or associated ear pain from the inflammation.

    The simplest things you can do are this:

    1. Stop chewing gum for the time being.
    2. Use advil/aleve for the inflammation.
    3. Use a hot pad at the joint of the jaw for 10 minutes a few times a day.  This will help loosen up the joint, tendon and muscles.
    4. Gently massage the joint.

    What sleeping position helps relieve pressure after an appendectomy?

    Although not a wonderful sleeping position for everyone, sleeping flat on your back or with a pillow under your knees will put the least amount of pressure on your abdomen.

    If you do need to move to keep from getting stiff you might find that placing a pillow under your right side might help (this puts the right side slightly elevated).  If it’s done the other direction it can sometimes put more pressure on the lower right quadrant which is what you want to avoid.

    If your surgery was a laparoscopy without complications you’ll likely feel better within 2 weeks although some people will be sore for longer.  Always stay in contact with your doctor if you have knew or persistent pain that isn’t healing.  In rare cases the stump of the appendix that is left behind can become inflamed will mimic all of the effects of full blown appendicitis (which is exactly what it is, just on the stump).